Epigenome Wide Association Studies



              

              

                

                  
                  
                

              

            

            

              

                

                  

                    
Then submit

                  

                  

                    
                  

                

              

            

            

              

                

                  

                    
Association statistics between the factor and CpGs sites within the query gene: 

                  

                  

                    
                    
                    
                  

                

              

            

            

              

                

                  

                    
Associations for the selected CpGs sites: 

                  

                  

                    
Select CpGs sites points on the graph below

                    

                  

                

              

            

            

              

                

                  

                    
Effect size plot between the selected factor and CpGs sites

                  

                  

                    
You can brush many points, they will appear in the 'Associations for the selected CpGs sites' track

                    

                  

                

              

            

            

              

                

                  

                    
Ensembl Gene visual track

                  

                  

                    
Please wait until the end of the process, this may take some time

                    
                    
                  

                

              

            

          

          

            
Methylation Quantitative Trait Loci

            

            
            

              

                

                  

                    

                      

                        
                        
                      

                    

                    

                      

                        
                        
                      

                    

                  

                  

                    

                      

                        

                          
Then submit

                        

                        

                          
                        

                      

                    

                  

                  

                    

                      

                        

                          
CpGs inside query Gene: 

                        

                        

                          
Please select one row and wait until association statistics appear below

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
SNPs/CpG site association statistics

                        

                        

                          
You can select one row to highlight the related point in graph below

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Associations for the selected SNP: 

                        

                        

                          
Select SNPs points on the graph below

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Manhattan plot between query CpG and surrounding SNPs: 

                        

                        

                          
You can brush many points, they will appear in the 'Associations for the selected SNP' track

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Ensembl Gene visual track

                        

                        

                          
Please wait until the end of the process, this may take some time

                          
                          
                        

                      

                    

                  

                

                

                  

                    

                      

                        
                        
                      

                    

                    

                      

                        
                        
                      

                    

                  

                  

                    

                      

                        

                          
Then submit

                        

                        

                          
                        

                      

                    

                  

                  

                    

                      

                        

                          
CpGs sites/SNP association statistics :

                        

                        

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Associations for surrounding CpGs sites: 

                        

                        

                          
You can select one row to highlight the related point in graph below

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Associations for the selected CpGs sites: 

                        

                        

                          
Select CpGs sites points on the graph below

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Manhattan plot between query SNP and surrounding associated CpGs sites

                        

                        

                          
You can brush many points, they will appear in the 'Associations for the selected CpGs sites' track

                          

                        

                      

                    

                  

                  

                    

                      

                        

                          
Ensembl Gene visual track

                        

                        

                          
Please wait until the end of the process, this may take some time

                          
                          
                        

                      

                    

                  

                

              

            

          

          

            
Publications from Milieu Interieur Consortium

            

            
    
              
  1. 
                
    
                  
    Human thymopoiesis is influenced by a common genetic variant within the TCRA-TCRD locus
    
                  
    
                    Sci Transl Med.05.09.2018
                    
    
                    Clave E, Araujo IL, Alanio C, Patin E, Bergstedt J, Urrutia A, Lopez-Lastra S, Li Y, Charbit B, MacPherson CR, Hasan M, Melo-Lima BL, Douay C, Saut N, Germain M, Trégouët DA et al., Toubert A and The Milieu Interieur Consortium
                  
    
                  
    
                    Abstract: 
                    
    
                    The thymus is the primary lymphoid organ where naïve T cells are generated; however, with the exception of age, the parameters that govern its function in healthy humans remain unknown. We characterized the variability of thymic function among 1000 age- and sex-stratified healthy...
                  
    
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    2. 
              
  2. 
                
    
                  
    Human genetic variants and age are the strongest predictors of humoral immune responses to common pathogens and vaccines.
    
                  
    
                    Genome Med.27.07.2018
                    
    
                    Petar Scepanovic, Cécile Alanio, Christian Hammer, Flavia Hodel, Jacob Bergstedt, E. Patin, C. Wandall Thorball, N. Chaturvedi, B. Charbit, L. Abel, Lluis Quintana-Murci, Darragh Duffy, Matthew L. Albert, Jacques Fellay, The Milieu Intérieur Consortium
                  
    
                  
    
                    Background: 
                    
    
                    Humoral immune responses to infectious agents or vaccination vary substantially among individuals, and many of the factors responsible for this variability remain to be defined. Current evidence suggests that human genetic variation influences (i) serum immunoglobulin levels, (ii)...
                  
    
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    3. 
              
  3. 
                
    
                  
    Natural variation in the parameters of innate immune cells is preferentially driven by genetic factors
    
                  
    
                    Nature Immunology-23.02.2018
                    
    
                    Etienne Patin, Milena Hasan, Jacob Bergstedt, Vincent Rouilly et al. and The Milieu Intérieur Consortium
                  
    
                  
    The quantification and characterization of circulating immune cells provide key indicators of human health and disease. To identify the relative effects of environmental and genetic factors on variation in the parameters of innate and adaptive immune cells in homeostatic conditions, we combined...
    
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    4. 
              
  4. 
                
    
                  
    The Milieu Intérieur study - an integrative approach for study of human immunological variance
    
                  
    
                    Clinical Immunology-03.01.2015
                    
    
                    Thomas S, Rouilly V, Patin E, Alanio C, Dubois A, Delval C, Marquier LG, Fauchoux N, Sayegrih S, Vray M, Duffy D, Quintana-Murci L, Albert ML; for The Milieu Intérieur Consortium.
                  
    
                  
    
                    Abstract
                    
    
                    The Milieu Intérieur Consortium has established a 1000-person healthy population-based study (stratified according to sex and age), creating an unparalleled opportunity for assessing the determinants of human immunologic variance. Herein, we define the criteria utilized for participant...
                  
    
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    5. 
              
  5. 
                
    
                  
    Distinctive roles of age, sex, and genetics in shaping transcriptional variation of human immune responses to microbial challenges.
    
                  
    
                    Proc Natl Acad Sci U S A.27.12.2017
                    
    
                    Piasecka B, Duffy D, Urrutia A, Quach H, Patin E, Posseme C, Bergstedt J, Charbit B, Rouilly V, MacPherson CR, Hasan M, Albaud B, Gentien D, Fellay J, Albert ML, Quintana-Murci L; Milieu Intérieur Consortium
                  
    
                  
    
                    Abstract: 
                    
    
                    The contribution of host genetic and nongenetic factors to immunological differences in humans remains largely undefined. Here, we generated bacterial-, fungal-, and viral-induced immune transcriptional profiles in an age- and sex-balanced cohort of 1,000 healthy individuals and...
                  
    
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    6. 
              
  6. 
                
    
                  
    Associations between usual diet and gut microbiota composition: results from the Milieu Intérieur cross-sectional study
    
                  
    
                    The American Journal of Clinical Nutrition, Volume 109, Issue 5, May 2019, Pages 1472–1483
                    
    
                    Valentin Partula, Stanislas Mondot, Marion J Torres, Emmanuelle Kesse-Guyot, Mélanie Deschasaux, Karen Assmann, Paule Latino-Martel, Camille Buscail, Chantal Julia, Pilar Galan, Serge Hercberg, Vincent Rouilly, Stéphanie Thomas, Lluis Quintana-Murci, Matthew L Albert, Darragh Duffy, Olivier Lantz, Mathilde Touvier, the Milieu Intérieur Consortium
                  
    
                  
    Diet is widely recognized as one of the main modifiable drivers of gut microbiota variability, and its influence on microbiota composition is an active area of investigation...
    
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    7. 
              
  7. 
                
    
                  
    A comprehensive assessment of demographic, environmental, and host genetic associations with gut microbiome diversity in healthy individuals 
    
                  
    
                    Microbiome volume 7, Article number: 130 (2019)
                    
    
                    Petar Scepanovic, Flavia Hodel, Stanislas Mondot, Valentin Partula, Allyson Byrd, Christian Hammer, Cécile Alanio, Jacob Bergstedt, Etienne Patin, Mathilde Touvier, Olivier Lantz, Matthew L. Albert, Darragh Duffy, Lluis Quintana-Murci, Jacques Fellay & The Milieu Intérieur Consortium
                  
    
                  
    The gut microbiome is an important determinant of human health. Its composition has been shown to be influenced by multiple environmental factors and likely by host genetic variation. In the framework of the Milieu Intérieur Consortium, a total of 1000 healthy individuals of western European ancestry, with a 1:1 sex ratio and evenly stratified across five decades of life (age 20–69), were recruited...
    
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    8. 
            

            

              To see more publication you can visit our website: 
              Milieu-Interieur.fr
            

          

          

            

              

                

                  

                    
You can download an archive per condition, containing all the factor.rds file :

                  

                  

                    

                      
                      

                        
                        
                      

                    

                    
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Contact Support

            
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